The Effect of Duration of Use of Depomedroxyprogesterone Acetate on the Thickness of the Vaginal Epithelium of Mice

BACKGROUND: Depomedroxyprogesterone acetate (DMPA) is one of the most effective contraceptive methods currently widely used. Injectable contraceptives, including DMPA, are growing in popularity because their ease use, effectiveness and affordability. The use DMPA also has advantages such as not interfering with sexual relations, does need male participation, require storage space, easy to obtain helps increase body weight.
 AIM: aim study was analyze effect duration on thickness vaginal epithelium mice.
 METHODS: research design used this true experimental a post-test only control group approach. This carried out treatment at dose 0.39 mg/mouse/day exposure mice. phenomenon observed mice completely randomized method Pharmacology Laboratory Anatomical Pathology Laboratory, FKH Unsyiah. collection data technique conducted by observation light microscope calculate average injected four groups. analysis five stages, namely, normality test sample Shapiro–Wilk test, homogeneity variance Levene comparing each two groups using independent t-test.
 RESULTS: finding revised that there significant difference 10 days 15 which indicated p = 0.003 (p < 0.05). levels cause thinning epithelial thickness. for 182536.33 ± 5773.465. In group, days, 168322.33 7611.300. mean 15-day 177242.83 9689.558. 138674.83 17176.124.
 CONCLUSION: There between exposure. longer thinner epithelium.